Nanozeolite‐LTL with GdIII Deposited in the Large and EuIII in the Small Cavities as a Magnetic Resonance Optical Imaging Probe |
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Authors: | Florian Mayer Wuyuan Zhang Thomas Brichart Prof Olivier Tillement Dr Célia S Bonnet Dr Éva Tóth Dr Joop A Peters Dr Kristina Djanashvili |
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Institution: | 1. Department of Biotechnology, Delft University of Technology, Julianalaan 136, 2628 BL Delft (The Netherlands), Fax: (+31)?152781415;2. Institut Lumière Materière, Université Claude Bernard Lyon 1, Rue V. Grignard, 69622 Villeurbanne Cedex (France);3. Centre de Biophysique Moleculaire, CNRS, Rue Charles Sadron, 45071 Orleans Cedex 2 (France) |
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Abstract: | The immense structural diversity of more than 200 known zeolites is the basis for the wide variety of applications of these fascinating materials ranging from catalysis and molecular filtration to agricultural uses. Despite this versatility, the potential of zeolites in medical imaging has not yet been much exploited. In this work a novel strategy is presented to selectively deposit different ions into distinct framework locations of zeolite‐LTL (Linde type L) and it is demonstrated that the carefully ion‐exchanged Gd/Eu‐containing nanocrystals acquire exceptional magnetic properties in combination with enhanced luminescence. This smart exploitation of the framework structure yields the highest relaxivity density (13.7 s?1 L g?1 at 60 MHz and 25 °C) reported so far for alumosilicates, rendering these materials promising candidates for the design of dual magnetic resonance/optical imaging probes, as demonstrated in preliminary phantom studies. |
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Keywords: | bimodal imaging ion relocation lanthanides luminescence relaxivity zeolites |
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