Preparation of Highly Efficient MRI Contrast Agents through Complexation of Cationic GdIII‐Containing Metallosurfactant with Biocompatible Polyelectrolytes |
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| Authors: | Yingying Chen Qin Zhu Xinghui Cui Weijun Tang Heng Yang Prof. Yuan Yuan Prof. Aiguo Hu |
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| Affiliation: | 1. Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237 (P.R. China);2. The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237 (P.R. China);3. Department of Radiology, Huashan Hospital Affiliated to Fudan University, Shanghai, 200040 (P.R. China) |
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| Abstract: | Novel contrast agents were developed through assembling of GdIII‐containing metallosurfactant (MS) with biocompatible polyelectrolytes sodium hyaluronate (HA), heparinsodium (HS) and dextran sulfate sodium (DSS). The formed polyelectrolyte–surfactant complexes showed different structural patterns as the charge ratio increased, including spherical aggregates, rod‐like aggregates and network patterns in monovalent HA system, while spherical structures emerged in multivalent HS and DSS systems. Energy dispersive spectroscopy analysis and scanning electron microscopy mapping showed the presence of GdIII in these complexes. Inductively coupled plasma atomic emission spectrometry was further used to quantify the contents of GdIII in the assemblies. T1 magnetic resonance imaging showed that these GdIII‐loaded complexes exhibited relaxivity of up to 63.81 mM ?1 s?1, much higher than that of Ominiscan (4.64 mM ?1 s?1). The cytotoxicity test in vitro demonstrated the excellent biocompatibility of these complexes, which is essential for clinical application. |
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| Keywords: | aggregates imaging agents magnetic resonance imaging polyelectrolytes surfactants |
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