Strong Induced‐Fit Binding of Viologen and Pyridine Derivatives in Adjustable Porphyrin Cavities

The synthesis and binding properties of new porphyrin cage compounds consisting of a rigid diphenylglycoluril part, which is connected via flexible bis(ethyleneoxy) spacers to a (metallo)porphyrin “roof”, are reported. Binding of viologen guests and pyridine ligands in these porphyrin cages are accompanied by significant conformational reorganizations of the hosts. Despite these structural changes, association constants are still very high, revealing that not only receptors that bind guests according to a lock‐and‐key mechanism but also those that bind guests by an induced‐fit mechanism can exhibit strong binding.