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Drug Conjugation to Cyclic Peptide–Polymer Self‐Assembling Nanotubes |
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| Authors: | Dr. Bianca M. Blunden Dr. Robert Chapman Dr. Maarten Danial Dr. Hongxu Lu Prof. Katrina A. Jolliffe Prof. Sébastien Perrier Prof. Martina H. Stenzel |
| Affiliation: | 1. Centre for Advanced Macromolecular Design, School of Chemistry, University of New South Wales, Sydney, NSW 2052 (Australia);2. Cooperative Research Centre (CRC) for Polymers, 8 Redwood Drive, Notting Hill, Victoria 3618 (Australia);3. Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, Sydney, NSW 2006 (Australia);4. School of Chemistry, The University of Sydney, Sydney, NSW 2006 (Australia);5. Department of Chemistry, The University of Warwick, Coventry CV4 7AL (UK);6. Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) |
| Abstract: | We show for the first time how polymeric nanotubes (NTs) based on self‐assembled conjugates of polymers and cyclic peptides can be used as an efficient drug carrier. RAPTA‐C, a ruthenium‐based anticancer drug, was conjugated to a statistical co‐polymer based on poly(2‐hydroxyethyl acrylate) (pHEA) and poly(2‐chloroethyl methacrylate) (pCEMA), which formed the shell of the NTs. Self‐assembly into nanotubes (length 200–500 nm) led to structures exhibiting high activity against cancer cells. |
| Keywords: | drug conjugation nanotubes peptides ruthenium self‐assembly |