Direct Assembly of 2‐Oxazolidinones by Chemical Fixation of Carbon Dioxide |
| |
| Authors: | Teemu Niemi Dr. Jesus E. Perea‐Buceta Dr. Israel Fernández Dr. Sami Alakurtti Erika Rantala Prof. Timo Repo |
| |
| Affiliation: | 1. Laboratory of Inorganic Chemistry, Department of Chemistry, University of Helsinki, P.O. Box 55, 00014 Helsinki (Finland), Fax: (+358)?9‐191‐50198;2. Departamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid (Spain);3. VTT Technical Research Centre of Finland, P. O. Box 1000, FI‐02044 (Finland) |
| |
| Abstract: | The reaction of β‐ and γ‐haloamines with carbon dioxide to give pharmaceutically relevant 2‐oxazolidinones and 1,3‐dioxazin‐2‐ones, was found to proceed efficiently in the presence of a base and in the absence of catalyst. After optimization of reaction conditions, the system was successfully expanded to a variety of haloamines, even at multigram scale. The reaction was further studied in silico by DFT calculations. |
| |
| Keywords: | 2‐oxazolidones antibiotics carbon dioxide activation carbon dioxide fixation density functional calculations |
|
|
