Mechanical Downsizing of a Gadolinium(III)‐based Metal–Organic Framework for Anticancer Drug Delivery |
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Authors: | Tanay Kundu Shouvik Mitra Prasun Patra Dr Arunava Goswami Prof?Dr David Díaz?Díaz Dr Rahul Banerjee |
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Institution: | 1. Physical/Materials Chemistry Division, CSIR‐National Chemical Laboratory, Dr. Homi Bhabha Road, Pune‐411008 (India), Fax: (+91)?20‐25902636;2. AERU, Biological Sciences Division, Indian Statistical Institute, Kolkata, 700108 (India);3. Institut für Organische Chemie, Universit?t Regensburg, Universit?tsstrasse 31, 93053 Regensburg (Germany);4. IQAC‐CSIC, Jordi Girona 18‐26, Barcelona 08034 (Spain) |
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Abstract: | A GdIII‐based porous metal–organic framework (MOF), Gd‐pDBI, has been synthesized using fluorescent linker pDBI (pDBI=(1,4‐bis(5‐carboxy‐1H‐benzimidazole‐2‐yl)benzene)), resulting in a three‐dimensional interpenetrated structure with a one‐dimensional open channel (1.9×1.2 nm) filled with hydrogen‐bonded water assemblies. Gd‐pDBI exhibits high thermal stability, porosity, excellent water stability, along with organic‐solvent and mild acid and base stability with retention of crystallinity. Gd‐pDBI was transformed to the nanoscale regime (ca. 140 nm) by mechanical grinding to yield MG‐Gd‐pDBI with excellent water dispersibility (>90 min), maintaining its porosity and crystallinity. In vitro and in vivo studies on MG‐Gd‐pDBI revealed its low blood toxicity and highest drug loading (12 wt %) of anticancer drug doxorubicin in MOFs reported to date with pH‐responsive cancer‐cell‐specific drug release. |
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Keywords: | ball‐milling doxorubicin drug delivery metal– organic frameworks nanocarriers |
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