Separation of nicotine metabolites by capillary zone electrophoresis and capillary zone electrophoresis/mass spectrometry |
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| Authors: | Palmer M E Smith R F Chambers K Tetler L W |
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| Institution: | Division of Chemistry, Sheffield Hallam University, Howard St., Sheffield S1 1WB, UK. |
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| Abstract: | The use of capillary zone electrophoresis (CZE) and capillary zone electrophoresis/mass spectrometry (CZE/MS) has been demonstrated, in principle, for the separation of nicotine and nicotine metabolites. The buffer system developed for separation and detection by CZE/UV was modified for use in CZE/MS analysis. Several of the metabolites are isobaric and tandem mass spectrometric (MS/MS) techniques have been used to differentiate such analytes. |
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