Straightforward three-component synthesis of diarylmethylpiperazines and 1,2-diarylethylpiperazines |
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Authors: | Stéphane Sengmany Cédric Le Jean Michel Troupel Jean-Yves Nédélec |
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Institution: | Laboratoire d'Electrochimie, Catalyse et Synthèse Organique, LECSO, CNRS-Université Paris 12 Val de Marne, UMR 7582, 2-8 rue Henri Dunant, 94320 Thiais, France |
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Abstract: | Several functionalized diarylmethylpiperazines and 1,2-diarylethylpiperazines have been synthesized in moderate to high yield according to a one-step three-component coupling between an aromatic or a benzylic organozinc reagent, a piperazine derivative, and an aromatic aldehyde. The procedure can be extended to the synthesis of benzylpiperazine derivatives or β-arylethylpiperazines toward the use of paraformaldehyde or aliphatic aldehydes. |
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Keywords: | Diarylmethylpiperazines 1 2-Diarylethylpiperazines Three-component reaction Arylzinc reagents Benzylzinc reagents |
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