一种基于联萘衍生物荧光探针的合成及其对精氨酸的识别

构建了一种基于(R)-2,2'-二羟基-1,1'-联萘]-3-醛的荧光探针。 通过核磁共振波谱仪(NMR)以及质谱(MS)等技术手段对其结构进行了表征。 结果表明,该荧光探针能够灵敏、高选择性地检测精氨酸,并显示出颜色和强烈的荧光变化双重响应。 相应的荧光增强比值与精氨酸的浓度(0~30 μmol/L)呈现良好的线性关系,相关系数R²为0.9914,检测限低至1.3 μmol/L。 此外,精氨酸的加入还促使该探针结构中的联萘酚手性结构发生偏转。

Synthesis of Binol-based Fluorescence Probe and Recognition of Arginine

A kind of fluorescence probe based on (R)-2,2'-dihydroxy-1,1'-binaphthalene]-3-carboxaldehyde was constructed. The structure was characterized by hydrogen/carbon nuclear magnetic resonance spectroscopy(¹H NMR, ¹³C NMR) and mass spectrometry(MS). The results show that the fluorescent probe can detect arginine in a sensitive and highly selective manner with a double response of color and intense fluorescence. The corresponding fluorescence enhancement ratio is in good linear relation with the concentration of arginine(0~30 μmol/L), the correlation coefficient R² is 0.9914 and the lowest detection limit is 1.3 μmol/L. In addition, the addition of arginine also caused the chiral structure of the probe to deflect, and the changes of binaphthol derivative axial chiral were verified by the changes of the circular dichromatic spectrum.