苯甲酰咪唑过氧化反应

以苯甲酰咪唑和叔丁基过氧化氢为反应物,1,8-二氮杂二环十一碳-7-烯(DBU)为催化剂,乙睛(CH₃CN)作为反应溶剂,合成了过氧化叔丁酯类化合物。 分别考察了不同催化剂及其用量、原料配比、溶剂、温度和时间对反应的影响,在最优条件下,共得到25个目标产物,收率范围为45%~99%。 目标化合物经核磁共振氢谱、核磁共振碳谱以及质谱进行了结构表征。 该方法具有操作简单、反应条件简单温和、产物收率高及底物适用性好等优点,为过氧化叔丁酯类化合物的合成提供了新的思路。

Peroxidation of Benzoylimidazole

In this paper, the experimental methods for the synthesis of t-butyl peroxide compounds were discussed, in which benzoyl imidazole and t-butyl hydroperoxide(TBHP) were used as reactants, 1,8-diazabicycloundec-7-ene(DBU) was used as the catalyst and acetonitrile(CH₃CN) was used as the reaction solvent. The effect of catalysts and their dosage, raw material ratios, solvents and temperature on the yield were investigated. A total of 25 target products were obtained under the optimum conditions with yields of 45%~99%. The molecular structures of the products were analyzed by nuclear magnetic resonance spectroscopy(¹H NMR and ¹³C NMR) and mass spectrometry. The method has the advantage of easily available material, easy operation, mild reaction conditions and a wide range of functional group tolerance, and has provided a new idea for the synthesis of t-butyl peroxide compounds.