布洛芬插层类水滑石/淀粉凝胶复合物的制备及缓释行为

为设计新型布洛芬缓释体系提供实验依据,以氯化镁、氯化铝、布洛芬(IBU)及淀粉等为原料,采取共沉淀-焙烧还原法及冷冻-解冻法,制备了层状双氢氧化物-布洛芬插层复合物(LDH-IBU)、淀粉凝胶-布洛芬复合物(淀粉凝胶-IBU)及层状双氢氧化物/淀粉凝胶-布洛芬插层复合物(LDH/淀粉凝胶-IBU)。 通过傅里叶红外光谱仪(FT-IR)、X射线衍射仪(XRD)表征了上述3种复合物的结构,并研究了它们在模拟人体环境条件下的缓释性能。 结果表明,3种复合物中的IBU在不同的缓释介质中都具有一定的缓释效果,复合物释放速率大小为:LDH/淀粉凝胶-IBU>LDH-IBU>淀粉凝胶-IBU;在pH值为6.6和7.4以及0.9%生理盐水3种缓冲介质中释放速率依次减小。 释放动力学均符合准一级动力学方程。

Preparation and Release Behavior of Ibuprofen Intercalated Hydrotalcite/Starch Gel Composites

To provide experimental basis for the design of new ibuprofen(IBU) sustained release system, the layered double hydroxide-ibuprofen intercalation compound(LDH-IBU), the starch gel-ibuprofen(starch gel-IBU) compound and layered double hydroxide/starch gel-ibuprofen(LDH/starch gel-IBU) intercalation compound were prepared by co-precipitation, roasting reduction and freeze-thaw methods based on magnesium chloride hexahydrate, aluminum chloride hexahydrate, IBU and starch as raw materials. The structures of three kinds of above composites were characterized by Fourier transform infrared spectrometer(FT-IR) and X-ray diffractometer(XRD). Their controlled release properties under the condition of simulated human body environment were studied. The results show that IBU in three kinds of complexes in different release media has certain controlled release effect. The release rates decrease in the order of LDH/starch gel-IBU, LDH-IBU and starch gel-IBU. The release rates in 3 buffer media decrease in the order of pH=6.6, pH=7.4 and 0.9% normal saline. The release kinetics can be fitted to the pseudo-first order kinetic model.