Syntheses,Structures, and Biological Activity of NiII,PdII, and PtII Complexes with New Tetradentate Benzamidine Ligands |
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Authors: | Thi Bao Yen Nguyen Minh Hai Nguyen Ulrich Abram Hung Huy Nguyen |
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Affiliation: | 1. Department of Chemistry, Hanoi University of Science, Le Thanh Tong str.19, Hanoi, Vietnam;2. Institute of Chemistry and Biochemistry, Freie Universit?t Berlin, Fabeckstrasse 34–36, 14195 Berlin, Germany |
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Abstract: | N‐(Dialkylthiocarbamoyl)benzimidoyl chlorides react with o‐(salicylidenimine)benzylamine with formation of a novel class of tetradentate benzamidine ligands (H2LEt and H2LMorph), which readily react with Ni(CH3COO)2, [PdCl2(CH3CN)2], and [PtCl2(PPh3)2] under formation of complexes of the composition [M(LR)] [M = Ni ( 4 ), Pd ( 5 ), Pt ( 6 )]. In all complexes, H2LR is doubly deprotonated and bonded to the metal ion via its N2OS donor set and establishes a distorted square‐planar coordination sphere. The antiproliferative effects of the compounds on MCF‐7 and Hep‐G2 cells were studied. The complexes of H2LMorph are generally more active than those of H2LEt. While H2LEt and its complexes exhibit stronger effects on the Hep‐G2 line, the corresponding compounds of H2LMorph show almost equal effects on the two cell lines. In each series of compounds, the cytotoxicity increases in the order H2LR << 4 < 5 < 6 . |
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Keywords: | Nickel Palladium Platinum Benzamidines Cytotoxicity X‐ray structure |
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