金霉素对小麦根生长的毒性效应

四环素类抗生素因具有抗菌和促进畜禽动物生长的功效,被广泛应用于畜禽养殖业.由于畜禽对抗生素的吸收、代谢较少,30%~90%的抗生素都以本体药物的形式随畜禽粪便排出流入环境.以四环素类抗生素——金霉素为例,研究了金霉素对小麦根生长的毒性效应,建立了不同形态金霉素对小麦根系生长的毒性效应模型:1/EC50=f+/EC+50+f0/EC050+f-/EC-50+f2-/EC2-50,得到各形态金霉素对小麦根毒性强弱的排序:二价阴离子态一价阴离子态中性态阳离子态,共存Ca2+对金霉素毒性的影响与Ca2+以及金霉素的浓度有关.

The toxicity of chlortetracycline to wheat root

Antibiotics are widely used in livestock and poultry industry for their growth promoting and disease preventing effects. Being poorly absorbed and metabolized by animals, about 30% to 90% of antibiotics would get into the environment as original form. In this paper, chlortetracycline (CTC), as an example for tetracycline class antibiotics, was studied for its toxicity to wheat roots. A toxicity model was built for the influence of different CTC forms on the root growth inhibition:〖SX(〗1〖〗EC50〖SX)〗=〖SX(〗f+〖〗EC+50〖SX)〗 + 〖SX(〗f0〖〗EC050 + 〖SX(〗f-〖〗EC-50〖SX)〗 + 〖SX(〗f2-〖〗EC2-50〖SX)〗. The toxicity of various forms of CTC is followed as CTC2->CTC->CTC0>CTC+. The effects of co existed Ca2+ on the toxicity of CTC is related to the concentrations of both Ca2+ and CTC.