E-beam crosslinked,biocompatible functional hydrogels incorporating polyaniline nanoparticles |
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| Authors: | C Dispenza M-A Sabatino A Niconov D Chmielewska G Spadaro |
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| Institution: | 1. Dipartimento di Ingegneria Chimica, Gestionale, Informatica, Meccanica, Università degli Studi di Palermo, Viale delle Scienze Ed. 6, 90128 Palermo, Italy;2. CNR—Istituto di Biofisica (Palermo unit), Via U. La Malfa 153, 90146 Palermo, Italy;1. School of Biomedical Engineering, Science and Health Systems, Drexel University, 3401 Market St, Suite 345, Philadelphia, PA, USA;2. Exponent, Inc., 3440 Market St, Philadelphia, PA, USA;3. Formae, Inc., 250 W Lancaster Ave, Paoli, PA, USA;1. Laboratory of Fundamental Science on Ergonomics and Environmental Control, School of Aeronautic Science and Engineering, Beihang University, Beijing, 100191, PR China;2. School of Chemical and Process Engineering, University of Leeds, Leeds, LS2 9JT, UK;3. Department of Mechanical Engineering, Faculty of Engineering, University of Kufa, Iraq;1. Department of Materials Science and Engineering, Institute of Space Technology, 1-National Highway, Islamabad 44000, Pakistan;2. Department of Inorganic Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovicova 6, Mlynska Dolina, 842 15 Bratislava, Slovakia;3. State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi''an Jiaotong University, Xi’an, Shaanxi, China;4. Department of Experimental Physics, Faculty of Mathematics, Physics, and Informatics, Comenius University in Bratislava, 842 48 Bratislava, Slovakia;1. Institute of Chemical Industry of Forestry Products, CAF, Jiangsu Province Biomass Energy and Materials Laboratory, Nanjing 210042, China;2. Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China;1. Centre de Recherche Public Henri Tudor, Advanced Materials and Structures Department, 5 rue Bommel, L-4940 Hautcharage, Luxembourg;2. Université de Strasbourg, Faculté de Chirurgie Dentaire, 1 Place de l’Hôpital, 67000 Strasbourg, France;3. Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1121, 11 rue Humann, 67085 Strasbourg Cedex, France |
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| Abstract: | PANI aqueous nanocolloids in their acid-doped, inherently conductive form were synthesised by means of suitable water soluble polymers used as stabilisers. In particular, poly(vinyl alcohol) (PVA) or chitosan (CT) was used to stabilise PANI nanoparticles, thus preventing PANI precipitation during synthesis and upon storage. Subsequently, e-beam irradiation of the PANI dispersions has been performed with a 12 MeV Linac accelerator. PVA-PANI nanocolloid has been transformed into a PVA-PANI hydrogel nanocomposite by radiation induced crosslinking of PVA. CT-PANI nanoparticles dispersion, in turn, was added to PVA to obtain wall-to-wall gels, as chitosan mainly undergoes chain scission under the chosen irradiation conditions. While the obtainment of uniform PANI particle size distribution was preliminarily ascertained with laser light scattering and TEM microscopy, the typical porous structure of PVA-based freeze dried hydrogels was observed with SEM microscopy for the hydrogel nanocomposites. UV?visible absorption spectroscopy demonstrates that the characteristic, pH-dependent and reversible optical absorption properties of PANI are conferred to the otherwise optically transparent PVA hydrogels. Selected formulations have been also subjected to MTT assays to prove the absence of cytotoxicity. |
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