Radiation-induced synthesis and swelling properties of p(2-hydroxyethyl methacrylate/itaconic acid/oligo (ethylene glycol) acrylate) terpolymeric hydrogels |
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| Authors: | M Micic D Stamenic E Suljovrujic |
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| Institution: | 1. Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia;2. Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia;1. Deutsches Textilforschungszentrum Nord-West gGmbH (DTNW), Adlerstr. 1, 47798 Krefeld, Germany;2. Institut für Energie- und Umwelttechnik e.V. (IUTA), Bliersheimer Str. 60, 47229 Duisburg, Germany;3. Universität Duisburg-Essen, Physikalische Chemie and CENIDE, Universitätsstr. 2, 45141 Essen, Germany;1. Department of Physics, National Technical University of Athens, Zografou Campus, 15780 Athens, Greece;2. Institute of Surface Chemistry, 17 General Naumov Street, Kiev 03164, Ukraine;1. Boreskov Institute of Catalysis SB RAS, pr. Ac. Lavrentieva, 5, Novosibirsk 630090, Russia;2. National Research Tomsk Polytechnic University, Lenin av., 30, Tomsk 634050, Russia;3. State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Novosibirsk Region 630559, Russia |
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| Abstract: | Since it is presumed that by incorporation of pH-responsive (IA) and temperature-responsive (OEGA) co-monomers, it is possible to prepare P(HEMA/IA/OEGA) hydrogels with dual (pH and thermo) responsiveness, the main purpose of our study is to investigate the influence of different mole fractions of IA and especially OEGA on the diversity of the swelling properties of the obtained hydrogels. For that reason, a series of terpolymeric hydrogels with different mole ratios of 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and oligo(ethylene glycol) acrylates (OEGA) was synthesised by gamma radiation. The obtained hydrogels were characterised by swelling studies in the wide pH (2.2–9.0) and temperature range (20–70 °C), confirming dual (pH and thermo) responsiveness and a large variation in the swelling capability. It was observed that the equilibrium swelling of P(HEMA/IA/OEGA) hydrogels, for a constant amount of IA, increased progressively with an increase in OEGA share. On the other hand, the dissociation of carboxyl groups from IA occurs at pH>4; therefore, small mole fractions of IA render good pH sensitivity and a large increase in the swelling capacity of these hydrogels at higher pH values. Additional characterisation of structure and properties was conducted by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and mechanical measurements, confirming that the inherent properties of P(HEMA/IA/OEGA) hydrogels can be significantly tuned by variation in their composition. According to all presented, it seems that the obtained hydrogels can be a beneficial synergetic combination for controlled delivery of bioactive molecules such as drugs, peptides, proteins, etc. |
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