|
|||||
|
|
Synthesis of an influenza neuraminidase inhibitor intermediate via a highly diastereoselective coupling reaction |
|
| Authors: | Barnes David M McLaughlin Maureen A Oie Tetsuro Rasmussen Michael W Stewart Kent D Wittenberger Steven J |
| Institution: | Global Pharmaceutical R&D, Process Research & Development, Abbott Laboratories, 1401 Sheridan Road, D-R450, Bldg. R8, North Chicago, Illinois 60064-4000, USA. |
| Abstract: | reaction: see text]. A highly diastereoselective coupling reaction between TBSOP (3) and trityl sulfenimine 4 was developed which provided influenza neuraminidase inhibitor intermediate 7 in 80% yield and >99% de after crystallization. The reaction was shown to be reversible with the high diastereoselectivity resulting from a favorable H-bonding interaction in the major diastereomer. |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ | |