| Peptide Deravatives as New Chiral Ligands for Enantioselective Phenylacetylene Addition to Aldehydes |
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| 引用本文： | ZHOU,Yi-Feng GAO,Yan-Feng KANG,Yong-Feng HAN,Zhi-Jian YAN,Wen-Jin NI,Ming WANG,Rui. Peptide Deravatives as New Chiral Ligands for Enantioselective Phenylacetylene Addition to Aldehydes[J]. 有机化学, 2004, 24(Z1): 162 |
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| 作者姓名： | ZHOU Yi-Feng GAO Yan-Feng KANG Yong-Feng HAN Zhi-Jian YAN Wen-Jin NI Ming WANG Rui |
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| 作者单位： | ZHOU,Yi-Feng（State Key Laboratory of Applied Organic Chemistry, Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000） GAO,Yan-Feng（State Key Laboratory of Applied Organic Chemistry, Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000） KANG,Yong-Feng（State Key Laboratory of Applied Organic Chemistry, Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000） HAN,Zhi-Jian（State Key Laboratory of Applied Organic Chemistry, Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000） YAN,Wen-Jin（State Key Laboratory of Applied Organic Chemistry, Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000） NI,Ming（State Key Laboratory of Applied Organic Chemistry, Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000） WANG,Rui（State Key Laboratory of Applied Organic Chemistry, Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000） |
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| 摘 要： | The asymmetric addition of alkynylzinc to aldehydes is an important method of synthesizing chiral propargyl alcohols, which are important precursors to many chiral organic compounds. Recently, many significant chiral ligands in this area have been disclosed.[1] Use of a short peptide as a catalyst would allow expansion beyond the (still uncharted) repertoire of single amino acids, while conserving the advantages of a small molecule catalyst. To the best of our knowledge,no results of peptide derivatives as chiral ligands in this reaction has been disclosed to date.[2] Herein, we report the initial results of peptide derivatives, which have been used directly as a chiral ligand in this reaction (Scheme 1).
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Peptide Deravatives as New Chiral Ligands for Enantioselective Phenylacetylene Addition to Aldehydes |
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| ZHOU,Yi-Feng,GAO,Yan-Feng,KANG,Yong-Feng,HAN,Zhi-Jian,YAN,Wen-Jin,NI,Ming,WANG,Rui. Peptide Deravatives as New Chiral Ligands for Enantioselective Phenylacetylene Addition to Aldehydes[J]. Chinese Journal of Organic Chemistry, 2004, 24(Z1): 162 |
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| Authors: | ZHOU Yi-Feng GAO Yan-Feng KANG Yong-Feng HAN Zhi-Jian YAN Wen-Jin NI Ming WANG Rui |
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| Abstract: | The asymmetric addition of alkynylzinc to aldehydes is an important method of synthesizing chiral propargyl alcohols, which are important precursors to many chiral organic compounds. Recently, many significant chiral ligands in this area have been disclosed.[1] Use of a short peptide as a catalyst would allow expansion beyond the (still uncharted) repertoire of single amino acids, while conserving the advantages of a small molecule catalyst. To the best of our knowledge,no results of peptide derivatives as chiral ligands in this reaction has been disclosed to date.[2] Herein, we report the initial results of peptide derivatives, which have been used directly as a chiral ligand in this reaction (Scheme 1). |
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