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Solid-phase synthesis of C-terminal thio-linked glycopeptides |
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| Authors: | John P. Malkinson Robert A. Falconer |
| Affiliation: | aDepartment of Pharmaceutical and Biological Chemistry, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK |
| Abstract: | A solid-phase Mitsunobu reaction between a resin-bound 1-thiosugar and an N-Fmoc protected amino alcohol was successfully employed for thio-linked glycopeptide synthesis. Facile cleavage and deprotection in one step afforded the target glycopeptide in good yield and purity. |
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