| DNA机械技术的研究进展 |
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| 引用本文： | 孙梦雪,于婵婵,许敏,冯雪艳,姚立.DNA机械技术的研究进展[J].化学通报,2020,83(10):866-874,918. |
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| 作者姓名： | 孙梦雪 于婵婵 许敏 冯雪艳 姚立 |
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| 作者单位： | 中国科学院化学研究所北京分子科学国家研究中心分子动态与稳态结构实验室 北京 100190;中国科学院大学 北京100049;中国科学院化学研究所北京分子科学国家研究中心分子动态与稳态结构实验室 北京 100190;中国科学院大学 北京100049;中国科学院化学研究所北京分子科学国家研究中心分子动态与稳态结构实验室 北京 100190;中国科学院大学 北京100049;中国科学院化学研究所北京分子科学国家研究中心分子动态与稳态结构实验室 北京 100190;中国科学院大学 北京100049;中国科学院化学研究所北京分子科学国家研究中心分子动态与稳态结构实验室 北京 100190;中国科学院大学 北京100049 |
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| 基金项目： | (21778055)国家重点研发计划(2018YFA0208800)资助 |
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| 摘 要： | 近年来DNA机械技术得到了广泛的关注和深入的研究。DNA独特的分子结构和理化性质使构建DNA机械装置成为可能。通过设计更加精巧的机械装置可以产生更加复杂的机械行为或功能。DNA机械技术在研究感知、传递和产生pN力的生物分子的基本特性方面也发挥了重要作用，这些力学研究对于揭示它们的功能至关重要。本文总结了近年来DNA机械技术的研究进展。首先简要介绍DNA的机械力学基础，然后重点阐述几种DNA机械装置，最后讨论了DNA机械技术的挑战与展望。
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| 关 键 词： | DNA机械技术 分子机器 传感器 分子间相互作用 |
| 收稿时间： | 2020/6/15 0:00:00 |
| 修稿时间： | 2020/7/11 0:00:00 |
Advances in DNA Mechanical Technology |
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| Sun Mengxue,Yu Chanchan,Xu Min,Feng Xueyan,Yao Li.Advances in DNA Mechanical Technology[J].Chemistry,2020,83(10):866-874,918. |
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| Authors: | Sun Mengxue Yu Chanchan Xu Min Feng Xueyan Yao Li |
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| Institution: | Beijing National Laboratory for Molecular Sciences,State Key Laboratory for Structural Chemistry of Unstable and Stable Species,Institute of Chemistry,Chinese Academy of Science,Beijing,Beijing National Laboratory for Molecular Sciences,State Key Laboratory for Structural Chemistry of Unstable and Stable Species,Institute of Chemistry,Chinese Academy of Science,Beijing,Beijing National Laboratory for Molecular Sciences,State Key Laboratory for Structural Chemistry of Unstable and Stable Species,Institute of Chemistry,Chinese Academy of Science,Beijing,Beijing National Laboratory for Molecular Sciences,State Key Laboratory for Structural Chemistry of Unstable and Stable Species,Institute of Chemistry,Chinese Academy of Science,Beijing,Beijing National Laboratory for Molecular Sciences,State Key Laboratory for Structural Chemistry of Unstable and Stable Species,Institute of Chemistry,Chinese Academy of Science,Beijing |
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| Abstract: | DNA mechanical technology has been widely concerned and deeply studied in recent years. Mechanical DNA devices have been enabled by the the unique molecular structure and physical and chemical properties. More complex mechanical behavior or function can be achieved by designing more elaborate mechanisms. DNA mechanical technology has played important role in studies of the fundamental properties of the biomolecules that sense, transmit, and generate pN forces. Studies of the mechanics of these biomolecules are essential to revealing their functions. Here, we reviewed the latest progress in the study of DNA mechanical technology. First, the mechanical basis of DNA was briefly described. Especially several types of mechanical DNA devices were focused on. Finally, the challenges and prospects of DNA mechanical technology were discussed. |
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| Keywords: | DNA mechanical technology Molecular machine Sensor Molecular Interaction |
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