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Study of interaction between protein and main active components in Citrus aurantium L. by optical spectroscopy |
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| Authors: | Yantao Sun Haitao Zhang Yupu Zhang Jianhua Cheng Hanqi Zhang |
| Affiliation: | a College of Chemistry, Jilin University, Changchun 130012, PR China b College of Chemistry, Jilin Normal University, Siping 136000, PR China c College of Environmental and Resources, Jilin University, Changchun 130012, PR China d College of Chemistry, Changchun Normal University, Changchun 130032, PR China |
| Abstract: | The interaction between flavonoids and proteins was investigated by fluorescence and absorption spectroscopy. The binding parameters of drugs with proteins were obtained according to the corrected fluorescence data by an improved calculation method. The ΔH, ΔS and ΔG obtained indicate that the van der Waals or hydrogen bond, electrostatic force and hydrophobic forces all play a role in the interaction of drugs with proteins. Based on Förster's theory, the binding average distance r between the protein and drug was evaluated and found to be less than 3 nm. The interaction of drug-metal ion complexes and proteins was also investigated. |
| Keywords: | BSA HSA Hesperidin Naringin Interaction |
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