| 脱乙酰壳多糖─羧甲基纤维素聚电解质复合物的合成和药物控制释放研究 |
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| 引用本文： | 杨小钢,祝志峰,卓仁禧.脱乙酰壳多糖─羧甲基纤维素聚电解质复合物的合成和药物控制释放研究[J].离子交换与吸附,1999(4). |
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| 作者姓名： | 杨小钢 祝志峰 卓仁禧 |
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| 作者单位： | 武汉大学化学学院!武汉４３００７２ |
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| 摘 要： | 本文研究合成条件对脱乙酰壳多糖─羧甲基纤维素聚电解质复合物的组成、结构及药物控制释放性能的影响。结果表明，反应介质的ｐＨ值对生成的脱乙酰壳多糖─羧甲基纤维素聚电解质复合物的组成和结构的影响最大，在ｐＨ值５．５合成的脱乙酰壳多糖─羧甲基纤维素聚电解质复合物具有较好的药物控释性能。
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| 关 键 词： | 控制释放 聚电解质复合物 脱乙酸壳多糖 羧甲基纤维素 |
STUDIES ON THE PREPARATION AND DRUG DELIVERY OF CHITOSAN CARBOXYMETHYLCELLULOSE COMPLEXES |
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| Yang Xiaogang, Zhu Zhifeng, Zhuo Renxi.STUDIES ON THE PREPARATION AND DRUG DELIVERY OF CHITOSAN CARBOXYMETHYLCELLULOSE COMPLEXES[J].Ion Exchange and Adsorption,1999(4). |
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| Authors: | Yang Xiaogang Zhu Zhifeng Zhuo Renxi |
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| Abstract: | series of polyelectrolyte complexes of chitosan and carboxymethylcellulose had beenprepared via polymer interaction. The influence of preparation conditions on the chemicalcomposition and structure of the complexes was studied. The results showed that the PH value ofreaction medium was the most importal factor among those affecting the composition andstructure of the polyelectrolyte complexes formed. The polyelectrolyte complexes thus preparedat different pH were used for the stUdy of controlled release of antitumor drug 5-FU.Bettercontrolled release profile had been obtained in the case of polyelectrolyte complexes prepared atpH5.5. |
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| Keywords: | Controlled release Polyelectrolyte complex Chitosan Carboxymethylcellulose |
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