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Synthesis of the trisaccharide repeating unit of capsular polysaccharide from Klebsiella pneumoniae |
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| Authors: | Woen Susanto Kah-Hoe Kong Kuo-Feng Hua Shih-Hsiung Wu Yulin Lam |
| Institution: | 1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore;2. Department of Biotechnology and Animal Science, National Ilan University, No 1 Sec 1 Shennong Road, Yilan County 260, Taiwan;3. Institute of Biological Chemistry, Academia Sinica, 128 Academia Road Sec 2, Nankang, Taipei 115, Taiwan |
| Abstract: | The incidences of primary, pyrogenic liver abscess complicated by meningitis and septic endophthalmitis caused by Klebsiella pneumoniae has increased globally. Earlier studies have shown that the capsular polysaccharide (CPS) of Klebsiella pneumoniae plays an important role in the resistance to phagocytosis and related pathogenicity. The first chemical synthesis of the trisaccharide repeating unit of this CPS has been achieved via stereoselective glycosylation with orthogonal and appropriate protecting groups. A new method for the pyruvylation of trans diol was developed. |
| Keywords: | Trisaccharide CPS Pyruvylation Chemical synthesis |
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