Synthesis of 2,3,5,6-tetrasubstituted pyridines via selective three-component reactions of aldehyde and two different enaminones |
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| Authors: | Yi Li Guodong Wang Guifeng Hao Jie-Ping Wan |
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| Affiliation: | 1. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, PR China;2. Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou 310014, PR China |
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| Abstract: | The three-component synthesis of structurally unsymmetrical pyridines with polysubstituted structure has been realized via the catalytic system consisting of CuI and KHSO4. The employment of two different enaminones is the main factor allowing the successful [3+2+1] construction of the pyridine ring based on the formation of two C | |
| Keywords: | Enaminones Three-component Selective Pyridines Unsymmetrical |
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