Influence of poly(N‐isopropylacrylamide) and poly(N,N′‐diethyl acrylamide) coatings on polysulfone/polyacrylonitrile‐based membranes for protein separation |
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| Authors: | Telma Barroso Raquel Viveiros Margarida Coelho Teresa Casimiro Ana M Botelho do Rego Ana Aguiar‐Ricardo |
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| Institution: | 1. REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, , 2829‐516 Caparica, Portugal;2. Centro de Química‐Física Molecular (CQFM) and Institute of Nanoscience and Nanotechnology (IN),, Departamento de Engenharia Química e Biológica, Instituto Superior Técnico ‐ Universidade Técnica de Lisboa, , Lisboa, Portugal |
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| Abstract: | Herein we describe the design and the assembly of temperature sensitive polysulfone (PS)/polyacrylonitrile (PAN) blend membranes using supercritical fluid technology. Blended membranes were prepared using the CO2‐assisted phase inversion method, and their pores were coated with two thermoresponsive hydrogels‐poly(N‐isopropylacrylamide) (PNIPAAm) and poly(N,N′‐diethylacrylamide) (PDEAAm). Permeation experiments of bovine serum albumin (BSA) and lysozyme (LYS) solutions were used to evaluate the performance and temperature‐responsive behavior of coated membranes. While membranes coated with PNIPAAm presented similar protein permeation profiles at temperatures below and above its lower critical solution temperature, PDEAAm coating imparted a temperature‐responsive behavior to PS/PAN (90:10) membranes and selective permeation of proteins with different sizes. Copyright © 2011 John Wiley & Sons, Ltd. |
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| Keywords: | hydrogels supercritical carbon dioxide thermoresponsive membranes protein filtration |
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