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Recent applications of magnesium- and Zinc-TMP amides in the synthesis of bioactive targets |
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| Authors: | Rodolfo HV Nishimura Artur de LL Vaz Leandro A Bozzini Valter E Murie Giuliano C Clososki |
| Institution: | 1. Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, 14040-901, Ribeirão Preto SP, Brazil;2. Núcleo de Pesquisa em Produtos Naturais e Sintéticos, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. Do Café s/n, 14040-903, Ribeirão Preto SP, Brazil |
| Abstract: | Magnesium- and zinc-TMP amides have come out from relative obscurity to be recognized as important tools in modern synthetic chemistry. Development of LiCl-activated metal amides like TMPMgCl·LiCl and TMP2Zn·2MgCl2·2LiCl has been important to obtain new organometallic reagents through highly chemo- and regioselective reactions. Herein, we review how these reagents are applied in the synthesis of important bioactive targets such as natural products and drugs. |
| Keywords: | Magnesium amides Zinc amides Metalation Drug synthesis Natural products synthesis |
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