Synthese d'oligosaccharides sur polymere support—IV : Reactions sur polymere “popcorn” |
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Authors: | G Excoffier D Gagnaire J-P Utille M Vignon |
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Institution: | Centre de Recherches sur les Macromolécules Végétales, Centre National de la Recherche Scientifique, Domaine Universitaire. B.P. 53-38041 Grenoble, France |
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Abstract: | The different steps leading to oligosaccharide synthesis on polymeric support have been studied in the case of a functionalized ”popcorn” polystyrene: anchoring of the first glucidic group, unblocking of a selectively protected hydroxyl group, glycosylation and cleavage of the glucide support bond. The first glucidic unit is attached by a benzoic ester bond cleaved by methanolysis (Zemplén's method); β-benzoylpropionic ester was used as temporary protecting group. The synthesis of benzyl - 2 - acetamido - 4,6 - di - O - acetyl - 3 - O - (2 - acetamido - 3,4,6 - tri - O - acetyl - 2 - deoxy - β - D - glucopyranosyl) - 2 - deoxy - α - D - glucopyranoside is described as an example. |
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