Copper catalysed cross-dehydrogenative coupling (CDC) reaction of 4-thiazolidinone with terminal alkyne |
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| Authors: | Mohammedumar M Shaikh Anuj P Patel Kishor H Chikhalia |
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| Institution: | 1. Department of Chemistry, School of Science, Gujarat University, Ahmedabad, Gujarat, 380009 India;2. Department of Chemistry, Veer Narmad South Gujarat University, Surat, Gujarat, 395007 India |
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| Abstract: | Cross dehydrogenative coupling (CDC) strategy has been employed for C-alkynylation of 4-thiazolidinone with terminal alkyne under copper catalysis. Present reaction involves coupling of C(sp3) adjacent to sulfur of 4-thiazolidinone with C(sp) of terminal alkyne under CDC strategy is unprecedented to the best of our knowledge. Significant functional group tolerance, considerable yield and DFT study for mechanism make this synthetic task more interesting and compatible. |
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| Keywords: | Cross dehydrogenative coupling (CDC) 4-Thiazolidinone DFT study |
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