Synthesis,characterization and anticancer activity of 3-aminopyrazine-2-carboxylic acid transition metal complexes |
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| Authors: | Issam M Gabr Hala A El-Asmy Mohamed S Emmam Sahar I Mostafa |
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| Institution: | (1) Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt |
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| Abstract: | Synthetic procedures are described that allow access to the new complexes cis-Mo2O5(apc)2], cis-WO2(apc)2], trans-UO2(apc)2], Ru(apc)2(H2O)2], Ru(PPh3)2(apc)2], Rh(apc)3], Rh(PPh3)2(apc)2]ClO4, M(apc)2], M(PPh3)2(apc)]Cl, M(bpy)(apc)]Cl (M(II) = Pd, Pt), Pd(bpy)(apc)Cl], Ag(apc)(H2O)2] and Ir(bpy)(Hapc)2]Cl3, where Hapc, is 3-aminopyrazine-2-carboxylic acid. These complexes were characterized by physico-chemical and spectroscopic
techniques. Both Hapc and several of its complexes display significant anticancer activity against Ehrlich ascites tumour cells (EAC) in albino mice. |
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