| 正交实验法在 6-甲基丙烯酰氧基己磺酸钠合成中的应用 |
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| 引用本文： | 陈竹生,刘立辉,许炳智,陈慧英,刘婉如. 正交实验法在 6-甲基丙烯酰氧基己磺酸钠合成中的应用[J]. 化学学报, 1983, 41(11): 1077-1080 |
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| 作者姓名： | 陈竹生 刘立辉 许炳智 陈慧英 刘婉如 |
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| 作者单位： | 北京大学化学系;北京大学数学系 |
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| 摘 要： | 聚(6-甲基丙烯酰氧基)己磺酸钠(PSSHMA)是我们最近合成的、具有较好抗凝血性能的生物医用高分子材料.对具磺酸基聚合物的抗凝血性能的研究,报道尚少.我们用羟基己磺酸钠与甲基丙烯酸制备了新单体6-甲基丙烯酰氧基己磺酸钠(SSHMA) SSHMA的合成中仅氯化反应已有报道.本文用正交法对合成单体中的三步反应进行探索,找出了较好的反应条件,提高了产率.
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| 关 键 词： | 应用 钠化合物 酯化 磺酸盐 氯化反应 高聚物 磺化 医用高分子材料 甲基丙烯酸P 正交设计 |
Application of orthogonal designs in the synthesis of sodium 6-methacryloxyhexanesulfonate |
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| CHEN ZHUSHENG,LIU LIHUI,XU BINGZHI,CHEN HUIYING,LIU WANRU. Application of orthogonal designs in the synthesis of sodium 6-methacryloxyhexanesulfonate[J]. Acta Chimica Sinica, 1983, 41(11): 1077-1080 |
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| Authors: | CHEN ZHUSHENG LIU LIHUI XU BINGZHI CHEN HUIYING LIU WANRU |
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| Abstract: | The polymer of sodium 6-methacryloxyhexanesulfonate (SSHMA) showed improved anticoagulant activity. We applied orthogonal designs to study the optimal reaction conditions in the synthesis of SSHMA, which includes chlorination, sulfonation and esterification steps. Both the yields and purities of the products are improved. In the sulfonation of o-chlorohexanol, the use of large excess of sodium sulfite should be avoided. In the esterification of sodium o-hydroxyhexanesulfonate with excess methacrylic acid the presence of tetrbutyl ammonium hydrosulfate as phase transfer catalyst is an important factor. |
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| Keywords: | APPLICATION SODIUM COMPOUNDS ESTERIFICATION SULFONATE CHLORINATION REACTION HIGHPOLYMER SULFONATION MEDICAL MACROMOLECULAR MATERIAL METHYLPROPENOIC ACID P ORTHOGONAL DESIGN |
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