| 侧链带有脂肪族双季铵盐的赖氨酸的合成及抗菌性能分析 |
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| 引用本文： | 罗建斌,马晨.侧链带有脂肪族双季铵盐的赖氨酸的合成及抗菌性能分析[J].化学研究与应用,2008,20(7). |
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| 作者姓名： | 罗建斌 马晨 |
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| 作者单位： | 西南民族大学化学与环境保护工程学院,四川,成都,610041 |
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| 基金项目： | 西南民族大学基金资助项目 |
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| 摘 要： | 为了解决单季铵盐扩链剂所合成的聚氨酯对革兰氏阴性细菌不敏感的问题,文中合成了侧链带有脂肪族双季铵盐的赖氨酸作为聚氨酯的扩链剂(ED8)。用质谱、核磁共振对所合成的产物进行分析。最后,通过采用最低抑菌浓度(MIC)法对ED8进行抗菌性能测试发现,ED8对革兰氏阴性细菌的抗菌效果比单季铵盐扩链剂好8倍。
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| 关 键 词： | 抗菌 双季铵盐 扩链剂 |
Synthesis and antimicrobial properties of the lysine with pendant bis-ammonium salts |
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| LUO Jian-bin,MA Chen.Synthesis and antimicrobial properties of the lysine with pendant bis-ammonium salts[J].Chemical Research and Application,2008,20(7). |
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| Authors: | LUO Jian-bin MA Chen |
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| Abstract: | In order to resolve the increasing resistance phenomena of the Gram-negative cacteria against single chain quaternary ammonium salts(QAS),lysine with a pendant bis-ammonium salts is synthesized and its antimicrobial properties are evaluated in this work.The novel bis-ammonium salts shows similar activity with conventional single chain quaternary ammonium salts against Gram-positive bacteria but stronger activity against Gram-negative bacteria compared with the single chained counterpart. |
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| Keywords: | antimicrobial agents bis-ammonium salts chain extender |
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