Convergent synthesis and biological activity of the WXYZA'B'C' ring system of maitotoxin |
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| Authors: | Oishi Tohru Hasegawa Futoshi Torikai Kohei Konoki Keiichi Matsumori Nobuaki Murata Michio |
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| Institution: | Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan. oishi@chem.sci.osaka-u.ac.jp |
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| Abstract: | The WXYZA'B'C' ring system ( 1) of maitotoxin (MTX) was synthesized in a convergent manner via successive coupling of the W, Z, and C' ring fragments through construction of the XY and A'B' ring systems. The synthetic segment 1 blocked the hemolytic activity elicited by MTX. |
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