Palladium-catalyzed regiocontrolled alpha-arylation of trimethylsilyl enol ethers with aryl halides |
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| Authors: | Iwama Tetsuo Rawal Viresh H |
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| Affiliation: | Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, IL 60637, USA. |
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| Abstract: | Inter- and intramolecular arylations of trimethylsilyl enol ethers with aryl halides are accomplished regiospecifically in the presence of a palladium catalyst and tributyltin fluoride in refluxing benzene or toluene. The optimal catalyst system called for the use of Pd2(dba)3 and tri-tert-butylphosphine in ca. 1:2 ratio. Aryl iodides, bromides, and chlorides are all effective arylation partners in this reaction. [reaction: see text] |
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