SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW 8-HYDROXYQUINOLINE SULPHONAMIDE DERIVATIVES |
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| Authors: | Ali A Abdel Hafez Ibrahim M A Awad Khairy M Hassan |
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| Institution: | Chemistry Department, Faculty of Science , Assiut University , Assiut, Egypt |
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| Abstract: | Abstract Some new derivatives containing both 8-hydroxyquinoline and sulphonylamino β-lactams and thiazolidinones have been prepared. These compounds were synthesized from the corresponding 8-hydroxyquinoline sulphonylhydrazide (1) by converting it to hydrazones (2). The latter hydrazones (2) were easily transformed to β-lactams (3) and thiazolidinones (4) by cyclocondensation reaction with chloroacetyl chloride and/or mercaptoacetic acid. Some metal chelates with Fe3+. Co2++, Ni2+, Cu2+ and Cd2+ have been prepared for some of the compounds and screened in vitro for their biological activity. |
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| Keywords: | 9 10-dihydropyrrolo[3 4-b][1 4]benzoxazepine reaction with nucleophiles |
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