SYNTHESIS OF SYMMETRICAL AND UNSYMMETRICAL AMIDOPHOSPHITES

Abstract

A method is proposed for one-pot synthesis of either symmetrical or unsymmetrical diester amidophosphites, developed on the basis of tris-(N,N-dimethyl)-amide/or tris-(N,N-diethyl)-amide/of phosphorous acid, activated by iodine, as a new phosphorylating reagent.

Nine thiophosphate, phosphite and phosphite monoester and diester derivatives of 1-O-stearoyl-ethane-2-ol, cholesterol, β-sitosterol and R,S-α-tocopherol have been synthesized under mild conditions (20–75°C) and in high final yields (83--98%).