NEW RADIOHALOGENATED ALKENYL TELLURIUM FATTY ACIDS |
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Authors: | Prem C Srivastava Furn F Knapp Jr George W Kabalka |
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Institution: | 1. Oak Ridge National Laboratory , Oak Ridge, Tennessee, 37831;2. Chemistry Department , University of Tennessee , Knoxville, Tennessee, 37996 |
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Abstract: | Abstract Radiolabeled long-chain fatty acids have diagnostic value as radiopharmaceutical tools in myocardial imaging. Some applications of these fatty acids are limited due to their natural metabolic degradation in vivo with subsequent washout of the radioactivity from the myocardium. The identification of structural features which will increase the myocardial residence time without decreasing the heart uptake of long-chain fatty acids is of interest. Fatty acids containing the tellurium heteroatom were the first modified fatty acids developed and show unique prolonged myocardial retention and low blood levels. Our detailed studies with radioiodinated vinyliodide substituted tellurium fatty acids demonstrate that heart uptake is a function of the tellurium position. New techniques of tellurium and organoborane chemistry have been developed for the synthesis of a variety of radioiodinated iodoalkenyl tellurium fatty acids. |
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Keywords: | Dialkyl dithiophosphates phosphoric acids tantalum(V) isopropoxide tetraisoprop-oxytantalum(V) dialkyl dithiophosphates |
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