An Investigation by 31P-N.M.R. Spectroscopy into the Occurrence of High Energy Phosphates in Helminths (Worms) |
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| Authors: | Melvin R Euerby William A Gibbons Michele P Learmonth |
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| Institution: | Department of Pharmaceutical Chemistry , School of Pharmacy, University of London , 29-39 Brunswick Square, London , WC1N 1AX , England |
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| Abstract: | Abstract N-Phosphorylated guanidines (phosphagens,I), found in living tissue, act as high energy phosphate regulators of adenosine triphosphate. Vertebrates possess phosphocreatine (Ia) as their sole phosphagen whereas in invertebrates phosphoarginine (Ib) predominates. However, in certain non-parasitic helminths (Annelida), a novel class of phosphagens exists based on a phosphodiester structure (Ic) exemplified by phospholombricine (R′= CH2 CH(NH2)CO2H). |
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