O-[7-(1-Methylquinolinium)]-1,3,2-Dioxaphosphorinane 2-Oxide Iodide: A Reversible Anti-acetylcholinesterase and Irreversible Anti-butyrylcholinesterase Organophosphorus Ester |
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Authors: | Y Ashani D Levy |
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Institution: | Israel Institute for Biological Research , P.O. Box 19, Ness-Ziona , Israel |
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Abstract: | Abstract Although cyclic organophosphates(OP) esters (I) and their open-chain analogs (II) demonstrate similar reactivity of a P atom towards nucleophilic a. In order to compensate for overcrowding of the AChE active-site by large substituents it is essential to maintain flexibility of the four ligands attached to the P atom. It is further infered that cyclization does not permit such flexibility. b. BuChE differ considerably from AChE in the ability of the enzyme to provide simultaneous four-site interaction with tetrahedral OP inhibitors. |
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