Gui Yang XIE,Jia Hua CHEN*,Shrong Shi LIN,Sheng JIN Ministry of Education Key Lab of Bioorganic Chemistry &Molecular Engineering,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871
Abstract:
Antigen 12, containing a phosphonyl peptide hapten with free C-terminal carboxylic group, was synthesized by 11 reaction steps. The design of the hapten was based on the transition state of peptide hydrolysis catalyzed by carboxypeptidase A.