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The Synthesis of a Novel Phosphorus Containing Antigen
Authors:Gui Yang XIE  Jia Hua CHEN  Shrong Shi LIN  Sheng JIN Ministry of Education Key Lab of Bioorganic Chemistry &Molecular Engineering  College of Chemistry  Molecular Engineering  Peking University  Beijing
Affiliation:Gui Yang XIE,Jia Hua CHEN*,Shrong Shi LIN,Sheng JIN Ministry of Education Key Lab of Bioorganic Chemistry &Molecular Engineering,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871
Abstract:Antigen 12, containing a phosphonyl peptide hapten with free C-terminal carboxylic group, was synthesized by 11 reaction steps. The design of the hapten was based on the transition state of peptide hydrolysis catalyzed by carboxypeptidase A.
Keywords:Phosphonyl peptide   hapten   peptide hydrolysis.
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