Selective human serum albumin sensor from the screening of a fluorescent rosamine library |
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Authors: | Ahn Young-Hoon Lee Jun-Seok Chang Young-Tae |
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Institution: | Department of Chemistry, New York University, New York, New York 10003, USA. |
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Abstract: | A fluorescent dye library approach for the development of a bioanalyte sensor was sought. The screening of a rosamine dye library against diverse macromolecules led to the discovery of a highly sensitive human serum albumin binder, G13, with approximately 36-fold fluorescence intensity change. G13 showed a highly selective response to HSA over other macromolecules including albumins from other species. The potential use of G13 for the detection of HSA in biofluids is described. |
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