多孔β-磷酸三钙/壳聚糖/聚乙烯醇复合水凝胶的制备与性能

以NaCl为致孔剂,采用溶盐致孔法制备了多孔β-磷酸三钙/壳聚糖/聚乙烯醇（β-TCP/CS/PVA）复合水凝胶材料。 通过对比其含水率、溶胀比、拉伸强度、X射线衍射谱图、SEM和热重分析曲线，探讨了在相同环境下壳聚糖与β-磷酸三钙（β-TCP）的不同用量对聚乙烯醇(PVA)的结晶度以及对材料性能的影响。 此复合材料含水率为70%~76%。 当壳聚糖与β-TCP的质量比为2∶8时，复合材料的拉伸强度为0.56 MPa，断裂伸长率达到370%，其较好的力学性能，足以承受正常人眼压，可用作人工角膜周边支架材料。

Preparation and Properties of Porous β-Tricalcium Phosphate/Chitosan/Polyvinyl Alcohol Composite Hydrogel

Porous β-tricalcium phosphate/chitosan/polyvinyl alcohol(β-TCP/CS/PVA) composite hydrogel was prepared successfully by the freezing-thawing method using NaCl as porogen. The effects of different mass ratio of CS to β-TCP on the crystallinity of PVA and the performance of target β-TCP/CS/PVA composite hydrogel has been studied. The products were characterized by means of XRD, SEM， TG-DTA and their water uptake, swelling ratio, and tensile strength were also determined and compared. The water uptake of the hydrogel composite was about 70%~76%(mass fraction). When the mass ratio of CS to β-TCP was 2∶8, it exhibited good mechanical properties: tensile strength of 0.56 MPa and elongation at breakage of 370% which can withstand normal human eye pressure. Therefore, the porous β-TCP/CS/PVA hydrogel composite is promising to be used as the skirt for artificial cornea.