Synthesis and structure verification of the vaccine adjuvant QS-7-Api. Synthetic access to homogeneous Quillaja saponaria immunostimulants |
| |
Authors: | Deng Kai Adams Michelle M Gin David Y |
| |
Affiliation: | Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA. |
| |
Abstract: | QS-7-Api is an exceedingly potent immuno-adjuvant isolated from the bark of Quillaja saponaria. It is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccine clinical trials. Tedious isolation/purification protocols and uncertainty in its structural constitution have hindered the clinical development of QS-7. A chemical synthesis of QS-7-Api is described, providing structural verification of the adjuvant. A novel semisynthetic sequence to QS-7-Api has also been established, greatly facilitating access to QS-7 for preclinical and clinical evaluation. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|