Synthesis of the C12-C19 fragment of (+)-peloruside A through a diastereomer-discriminating RCM reaction |
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| Authors: | Roulland Emmanuel Ermolenko Mikhail S |
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| Institution: | Institut de Chimie des Substances Naturelles, CNRS, avenue de la Terrasse, 91198 Gif-sur-Yvette, France. |
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| Abstract: | reaction: see text]. A short and efficient asymmetric synthesis of the C12-C19 fragment of the cytotoxic macrolide (+)-peloruside A has been achieved via a highly diastereomer-discriminating RCM of alpha-branched but-3-enoate ester of a methallylic alcohol derived from hydrolytically resolved (S)-(-)-propylene oxide. |
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