Solid-phase total synthesis and structure proof of callipeltin B |
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| Authors: | Krishnamoorthy Ravi Vazquez-Serrano Leslie D Turk Jeffrey A Kowalski Jennifer A Benson Alan G Breaux Nneka T Lipton Mark A |
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| Institution: | Department of Chemistry and Cancer Center, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907-2084, USA. |
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| Abstract: | The cytotoxic, cyclic heptadepsipeptide, natural product callipeltin B was synthesized on a solid-phase support in 15% overall yield. Comparison of the 1H NMR spectra of three synthetic isomers with those of callipeltin B confirmed the configurational reassignment of its threonine residues as d-allothreonine and the assignment of the configuration of its beta-methoxytyrosine residue as (2R,3R). |
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