Simple Model Study of Phase Transition Properties of Isolated and Aggregated Protein |
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Authors: | Yong-Yun Ji Wei-Qi Yi Lin-Xi Zhang |
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Institution: | 1.Department of Physics,Wenzhou University,Wenzhou,P.R. China;2.Department of Physics,ZheJiang University,Hangzhou,P.R. China |
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Abstract: | We investigate the phase transition properties of isolated and aggregated protein by exhaustive numerical study in the confined
conformation space with maximally compact lattice model. The study within the confined conformation space shows some general
folding properties. Various sequences show different folding properties: two-state folding, three-state folding and prion-like
folding behavior. We find that the aggregated protein holds a more evident transition than isolated one and the transition
temperature is generally lower than that in isolated case. |
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Keywords: | |
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