Nucleic acid base pair dynamics: the impact of sequence and structure using free-energy calculations |
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| Authors: | Giudice Emmanuel Lavery Richard |
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| Institution: | Laboratoire de Biochimie Théorique, CNRS UPR 9080, Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, Paris 75005, France. |
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| Abstract: | Molecular dynamics free-energy calculations of base pair opening within double helical DNA and RNA are used to explain why A-tracts (oligo-adenine repeats) greatly increase the lifetimes of AT base pairs, whereas the structural and the chemical changes involved in passing from B-DNA to A-RNA have comparatively small effects. |
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