Two Zinc(II) and Nickel(II)‐based Complexes: Anti Breast Cancer Activity |
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| Authors: | Li‐Jing Cui Bin Zhang Chun‐Yan Liu Ming Bian |
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| Institution: | 1. School of Pharmacy, Guangdong Food and Drug Vocational College, Guangzhou, Guangdong, P. R. China;2. First Clinical Medical College, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P. R. China;3. Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia, P. R. China |
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| Abstract: | Two zinc(II) and nickel(II) based coordination polymers, {Zn(bibp)(MoO4)](H2O)2}n ( 1 ) bibp = 4,4′‐bis(imidazol‐1‐yl)‐biphenyl] and Ni2(CN)4(phen)2]n ( 2 ) (phen = 1,10‐phenanthroline), were synthesized and structurally characterized under solvothermal conditions. Compound 1 can be viewed as the connection of the 1D W‐type chain Zn(trans‐bibp)] with the MoO42– anion to form a uninodal 4‐connected net, whereas 2 features one‐dimensional NiII cyanide chains decorated either with linear Ni(CN)4 side chains or with 1,10‐phenanthroline ligands bound directly to the NiII sites of the parent chain. In addition, in vitro anticancer activities of compounds 1 and 2 on four human breast cancer cells (MDA‐MB‐231, MDA‐MB‐468, SK‐BR‐3, and MCF7) was further determined. |
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| Keywords: | Coordination polymer Solvothermal condition Breast cancer Zinc Nickel |
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