Interactions of xanthine and its derivatives with cyclodextrins in aqueous solutions |
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Authors: | I V Terekhova |
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Institution: | 1.Institute of Solution Chemistry,Russian Academy of Sciences,Ivanovo,Russian Federation |
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Abstract: | Using calorimetry, 1H NMR, UV spectroscopy, and solubility methods, the interactions of natural and hydroxypropylated 6h-, β-, and γ-cyclodextrins
with xanthine and its methylated derivatives (theophylline, theobromine, and caffeine) were studied in aqueous solutions at
298.15 K. Cyclodextrins revealed low complexation ability toward xanthine and its methylated derivatives. Hydroxypropyl-γ-cyclodextrin
with the largest internal cavity is the most effective solubilizing agent for this type of compounds. The calculated thermodynamic
parameters are discussed in terms of structural effects of cyclodextrins and purine alkaloids on the character of their intermolecular
interactions in aqueous medium. |
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Keywords: | |
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