Effect of blue light radiation on curcumin-induced cell death of breast cancer cells |
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| Authors: | X. B. Zeng A. W. N. Leung X. S. Xia H. P. Yu D. Q. Bai J. Y. Xiang Y. Jiang C. S. Xu |
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| Affiliation: | (1) Department of Dermatology, Jining First People’s Hospital, 6 Jiankang Road, 272111 Jining, Shandong Province, People’s Republic of China;(2) Department of Dermatology, Third Hospital of Hang Zhou, Hang Zhou Westlake Road, 310009 Hangzhou, Zhejiang Province, People’s Republic of China;(3) Central Lab, Jining First People’s Hospital, 6 Jiankang Road, 272111 Jining, Shandong Province, People’s Republic of China |
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| Abstract: | In the present study, we have successfully set up a novel blue light source with the power density of 9 mW/cm2 and the wavelength of 435.8 nm and then the novel light source was used to investigate the effect of light radiation on curcumin-induced cell death. The cytotoxicity was investigated 24 h after the treatment of curcumin and blue light radiation together using MTT reduction assay. Nuclear chromatin was observed using a fluorescent microscopy with Hoechst33258 staining. The results showed blue light radiation could significantly enhance the cytotoxicity of curcumin on the MCF-7 cells and apoptosis induction. These findings demonstrated that blue light radiation could enhance curcumin-induced cell death of breast cancer cells, suggesting light radiation may be an efficient enhancer of curcumin in the management of breast cancer. |
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