Synthesis of novel 6-substituted sulfur-containing derivatives of pyridoxine |
| |
| Authors: | Nikita V. ShtyrlinRoman S. Pavelyev Mikhail V. PugachevLubov P. Sysoeva Rashid Z. MusinYurii G. Shtyrlin |
| |
| Affiliation: | a Research and Educational Center of Pharmacy, Kazan Federal University, Kazan 420008, Russian Federation
b A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Centre of the Russian Academy of Sciences, Kazan 420088, Russian Federation |
| |
| Abstract: | An efficient synthesis of novel 6-substituted derivatives of pyridoxine was achieved. The reactions of various thiols with mono-, bis-, and tris(сhlorine) derivatives of 6-methyl-2,3,4-tris(hydroxymethyl)pyridin-5-ol (6-hydroxymethylpyridoxine) gave sulfur-containing derivatives of pyridoxine. |
| |
| Keywords: | Pyridoxine Nucleophilic substitution Sulfur nucleophiles Thioethers Protecting groups |
| 本文献已被 ScienceDirect 等数据库收录！ |
