Synthesis of novel 6-substituted sulfur-containing derivatives of pyridoxine |
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| Authors: | Nikita V ShtyrlinRoman S Pavelyev Mikhail V PugachevLubov P Sysoeva Rashid Z MusinYurii G Shtyrlin |
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| Institution: | a Research and Educational Center of Pharmacy, Kazan Federal University, Kazan 420008, Russian Federation
b A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Centre of the Russian Academy of Sciences, Kazan 420088, Russian Federation |
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| Abstract: | An efficient synthesis of novel 6-substituted derivatives of pyridoxine was achieved. The reactions of various thiols with mono-, bis-, and tris(сhlorine) derivatives of 6-methyl-2,3,4-tris(hydroxymethyl)pyridin-5-ol (6-hydroxymethylpyridoxine) gave sulfur-containing derivatives of pyridoxine. |
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| Keywords: | Pyridoxine Nucleophilic substitution Sulfur nucleophiles Thioethers Protecting groups |
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